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Hi Pete,
Last year I grow dozens of young loquat trees from seed, about 50% of them went through a stage of looking like this but in time they grew stronger and overcame it. I didn’t spray with anything but did give the young plants a but more shade in fear that the leaves were getting scorched and it seemed to help. As it’s growing in a pot it is also more susceptible to drought stress that can manifest it browning foliage.