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First thing I would do is to divide your large space into smaller rooms. This will make managing planting and themes much easier in the years to come, but will also dramatically improve the microclimates you’re planting in to. The exotic garden at Great Dixter is surrounded by a big thick yew hedge and is a great example of this. Take a look also at East Ruston Old Vicarage. Their plot was originally very exposed and they created warmer microclimates by planting a shelter belter around the whole area.